The Timeless Nemesis

The Nemesis of Folly

ing from consequences which were virtually certain to arrive, sooner or later. The exigencies of monthly publication preclude us from quoting figures which vary from day to day, and it must be enough to say that the number of cases at Gloucester Avhich have been diagnosed as small-pox has been so large that the utmost anxiety is reasonably felt as to when, and where, the epidemic will end. Thes...

Nemesis Reconsidered

The hypothesis of a companion object (Nemesis) orbiting the Sun was motivated by the claim of a terrestrial extinction periodicity, thought to be mediated by comet showers. The orbit of a distant companion to the Sun is expected to be perturbed by the Galactic tidal field and encounters with passing stars, which will induce variation in the period. We examine the evidence for the previously pro...

The Timeless Way of Building

The theory of architecture implicit in our world today, Christopher Alexander believes, is bankrupt. More and more people are aware that something is deeply wrong. Yet the power of present-day ideas is so great that many...

Medical nemesis?

Timeless tunes

Multiple structural, biochemical and in vivo studies have solidified the role that histone acetyltransferases (HATs) play in regulation of the p53 pathway. 1 HATs are known to modulate p53 functions in many ways, from regulating its stability to promoting acetyla-tion-dependent interactions with DnA as well as various co-factors and chromatin modi-fiers. 1 Of these, p300, CBP, PCAF and Tip60 ar...